Drug resistance, whether acquired as a result of inappropriate or inadequate chemotherapy or from an individual whose organism was drug resistant may present serious obstacles to the radication of tuberculosis.
The authors attempted direct drug susceptibility test to various primary and second line antitu-berculosis drugs on 139 isolates from pulmonary tuberculosis patients who have been hospitalized at Nationl Kongju Hospital for tuberculosis.
The results were summarized as follow:
1. Out of 101 tuberculosis patients, male patients were slightly more than female as a ratio of 1.59:1 and the average age of onset was 30 years.
2. The number of patients who have been suffered from pulmonary tuberculosis more than 6years was 61 (60.4%)
3. All of 139 isolated tubercle bacilii were resistant to one or more antituberculosis drugs.
4. Out ot 139 isolates, 94.2% was resistant to INH, 89.2% to EMB, 75.5% to SM, 63.3% to PZA, 56.1% to RMP, 47.5% to KM, 42.4% to PAS, 27.3% CS, 16.5% PTA and 2.9% to TUM.
5. Resistances to INH-SM-PAS, INH-SM-EMB.INH-SM-RMP, INH-EMB-RMP,PTA-PZA-CS and INH-SM-TUM were 36.0%, 69.1%,41.0%,46.8%,7.2% and 2.9%, respectively.
6. Resistances to INH-EMB-RMP-PZA and INH-SM-RMP-PZA were 31.7% and 27.3%, respectively.
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